The discovery of the medical quality of Saint Odile spring in Avène: A horse belonged to the Marquis of Rocozels was turned loose to roam the slopes of the Black Mountain in southwest of France due to a severe skin disease. It found a thermal spring near Avène. After drinking from the spring and rolling in its waters, the horse's coat became shiny again and soon it's skin disease was completely cured.

The Marquis of Rocozels, who was then the owner of the site, builds the first thermal spring facility in Avène to treat patients suffering from atopic dermatitis, eczema, psoriasis, and burns.

Avène's thermal spring facility is recommended by many scientific leaders in dermatology such as Jean-Louis Alibert.

Avène Thermal spring water is sent to the USA for victims of the Great Fire of Chicago

The reputation of the Avène thermal spring center quickly grows, and Avène Thermal spring water, known for its soothing properties to treat skin diseases, is acknowledged by the French government to be of "public benefit".

Avène Hydrotherapy center is approved for reimbursement by the French Social Security System.

Avène Hydrotherapy Center is purchased by Pierre Fabre Laboratories (the 2nd largest private pharmaceutical company in France today).

A full line of skincare products is created using Avène thermal spring water as the key ingredient to bring the benefits of Avène to the rest of the world.

Not far from the old baths, a new Avène Hydrotherapy Center is opened with modern day facilities to accommodate up to 2,000 patients. The Hydrotherapy Center is connected directly to the source of the spring to ensure the quality of Avène Thermal spring water.

Expansion of the Avène Hydrotherapy Center to accommodate to up to 4,000 patients.